Gonadotropin-Independent
Precocious Puberty
What is gonadotropin-independent precocious puberty?Early secretion (also called hypersecretion) of high levels of
the body's sex hormones, androgen (male sex hormones) and estrogen (female
sex hormones), can lead to the early outward appearance of puberty.
Sometimes called pseudoprecocious puberty, this form of early puberty is
characterized by the development of most secondary sexual characteristics,
although the sexual glands remain undeveloped.
What causes gonadotropin-independent precocious
puberty?The production of high levels of sex hormones in the young
child forces the onset of puberty characteristics.
What are the symptoms of gonadotropin-independent
precocious puberty? The following are the most common symptoms of
gonadotropin-independent precocious puberty. However, each child may
experience symptoms differently. Although the sexual glands themselves
remain immature, hypersecretion of androgen and estrogen cause the
development of most other secondary sexual characteristics. Symptoms may
include:
- girls:
- development of breasts
- underarm and pubic hair growth
- changes in body odor
- boys:
- facial, underarm, and pubic hair growth
- lengthening of penis
- appearance becomes more masculine
- changes in body odor
- acne
The s ymptoms of gonadotropin-independent precocious puberty may
resemble other problems or medical conditions. Always consult your child's
physician for a diagnosis.
How is gonadotropin-independent precocious puberty
diagnosed?In addition to a complete medical history and physical
examination, diagnosis of gonadotropin-independent precocious puberty may
include:
- x-ray - a diagnostic test which uses invisible
electromagnetic energy beams to produce images of internal tissues,
bones, and organs onto film.
- measurement of blood hormone levels
- ultrasound (Also called sonography.) of the adrenal glands and
pelvis a diagnostic imaging technique which uses high-frequency
sound waves and a computer to create images of blood vessels, tissues,
and organs. Ultrasounds are used to view internal organs as they
function, and to assess blood flow through various vessels.
- magnetic resonance imaging (MRI) - a diagnostic procedure
that uses a combination of large magnets, radiofrequencies, and a
computer to produce detailed images of organs and structures within the
body.
Treatment for gonadotropin-independent precocious
puberty:Specific treatment for gonadotropin-independent precocious will
be determined by your child's physician based on:
- your child's age, overall health, and medical history
- extent of the condition
- your child's tolerance for specific medications, procedures, or
therapies
- expectations for the course of the condition
- your opinion or preference
The goal of treatment for the hypersecretion of androgen and estrogen
is to stop, and possibly reverse, the onset of early puberty symptoms.
Treatment may include the use of certain medications that inhibit
the action of the sex hormones. If a tumor is causing the disorder,
surgical removal may be necessary.
More Information
Schneider Children's Hospital Division
of Endocrinology
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